Comparative Assessment of Glomerular Filtration Rate in Patients with Chronic Kidney Disease by the Cockcroft-Gault and MDRD Formulae in Conakry

Main Article Content

M L Kaba

Keywords

Chronic kidney disease, Cockcroft- Gault, MDRD

Abstract

Introduction: Epidemiological data show that the incidence of Chronic Kidney Disease (CKD) is increasing in all countries, developed or not. Our work was to estimate and compare the Glomerular Filtration Rate (GFR) calculated by the two formulae, CG (Cockcroft-Gault) and the MDRD (Modification of the Diet in the Renal Disease) in Chronic Kidney Disease patients in hospitals in Guinea.

Materials and method: The study was retrospective and descriptive from 2008 to 2010. The records examined were the number of 323 CKD cases out of 743 hospitalizations. The CKD was taken into account at stages 3, 4 and 5 i.e. moderate, severe and End-Stage Kidney Disease. Clearance calculations were made by the two formulae (CG and MDRD). Comparison parameters were patient's age, gender, and estimated glomerular filtration rate according to the stage of CKD.

Results: The prevalence of CKD was 43.5%. The average age of patients was 47 years [18-90]. The men were 174 (54%) in number and women 149 (46%) in number with a sex ratio of M / F = 1.2. The average serum creatinine was 672 ^mol/l [168-2854]. The estimated GFR was on average 16.2 ml / min by CG and 21.1 ml / min by MDRD. According to age, patients under 50 years were 202 (63%) in number by C-G and 210 (65%) in number by MDRD and those of over 50 years were 121 (37%) in number by CG against 113 (35%) by MDRD. According to gender and stage of CKD, men and women were 11% and 12% by C-G, 5% and 8% by MDRD for the stage 3; 14% and 15% by -C-G against 11 % and 11% by MDRD for the stage 4. At the stage 5 of CKD men were 28%, women 27% by C-G against 29% and 27% by MDRD respectively.

Conslusion: The two formulae are comparable in the proportion of patients categorized into each of the CKD stages.

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