State of the Art: “Hemodialysis” Dose and Survival in Acute Kidney Injury

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Chidi C Okafor
Emaad M Abdel-Rahman
Rasheed A Balogun

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Abstract

Acute kidney injury is increasingly being recognized as an independent correlate of poor outcomes, especially in hospitalized patients [1,2,3,4]. The incidence of AKI varies widely across different studies from different countries, in part due to different definitions and terminology [5]. There are very active efforts to establish both pharmacological and non-pharmacological therapeutic options for AKI. However, currently, the only approved treatment for established AKI by the US Food and Drug Administration is dialysis [6]. A minimum standard dose of dialysis has been established for patients on maintenance dialysis for ESRD (End Stage Renal Disease). This paper is a review of such efforts to determine the minimum effective dose of “hemodialysis” that has a positive effect on mortality in AKI patients. Some of the studies reviewed used hemofiltration solely or in combination with hemodialysis as therapy.

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